Non-Cellular Applications of Regenerative Medicine Treatments

Non-Cellular Applications of Regenerative Medicine Treatments

The goal of regenerative medicine procedures in general is to restore structure and function of damaged tissues and organs, and that is a very important point that distinguishes regenerative medicine procedures from conventional medicine procedures.  For example, we are not trying to just stop pain or to improve a joint through lubricating it or administering an anti-inflammatory medication.  The goal of the regenerative treatment is to restore the normal structure and function of the damaged tissue.

I previously discussed what are commonly referred to as stem cell treatments, which is a cellular regenerative medicine treatment, and now I am going to talk about non-cellular regenerative medicine treatments.  The difference is that non-cellular treatments do not contain cells.  Some of these treatments are cellular products such as proteins, but they are not cells.  That’s the difference between the two types of treatments, but the mechanism of actions and the treatment goals are very similar.  More specifically, the goal is the same and the action is similar.

It is very important for a doctor to be well-versed in both non-cellular and cellular treatments in order to be able to determine which specific treatment is more likely to help a specific patient for a specific condition.  This is why we call what we do personalized precision medicine.

I could use one of a number of non-cellular or cellular treatments to address a very similar condition in different patients.  One might ask, why are you using a different treatment for the same condition?  The reason is that everybody is different.  Everybody responds differently to the same treatment, and every person’s condition is unique.  Take high blood pressure as an example.  We all know that there are many blood pressure medications on the market.  If every medication works the same on every person, we would only need one blood pressure medication.   So, part of my job is to determine what treatment is most likely to help a specific patient for his or her specific condition.

Let’s start with oxygen ozone injection therapy which is a non-cellular regenerative treatment.  Oxygen ozone injection therapy is an extremely powerful regenerative medicine treatment.  It helps cells increase in number, which is called proliferation, by favorably influencing the redox system, which controls the cell cycle.  It also has multiple other properties such as increasing oxygen delivery to tissues and reducing inflammation in the body.  I have had a lot of successes using this injection therapy treating patients with disc herniations, joint pain, sports injuries and muscle spasm because of these unique properties.  Oxygen ozone can also be used to stimulate hair follicles to reproduce more hair and thicker hair by the same mechanisms that I described above.

Another non-cellular product with regenerative properties is exosomes.  Exosomes are an extremely fascinating cellular excretion product.  Exosomes are vacuoles that are excreted by cells which contain messenger RNA, micro RNA, and proteins. They are very powerful in activating the body’s own stem cells to help rejuvenate and repair damaged structures.  For example, exosomes can potentially stimulate repair of damaged cartilage, skin and nervous tissue which is a very powerful non-cellular regenerative repair mechanism within our body’s own amazing ability to heal.

A2M is another powerful non-cellular regenerative medicine treatment.   A2M is a protein that is naturally found in our body which can be concentrated and injected into various structures such as joints and discs.  A2M will capture and deactivate proteins that destroy cartilage.  It is a very important treatment if cartilage is being destroyed in a joint or in a disc since A2M can stop the process.  It also has growth factor binding sites, so it has regenerative properties.

These are some of the many treatments with non-cellular regenerative medicine.   Since I wrote a previous blog discussing cellular regenerative medicine treatments, I won’t go into it again.  The most important point, as I discussed above, is for a doctor to be well versed in all types of regenerative medicine treatments in order to be able to determine which of these non-cellular or cellular treatments are most appropriate for a specific patient in order to give the patient the best chance of healing.

Stem Cell Activating Treatments for Common Conditions

Stem Cell Activating Treatments for Common Conditions

How does regenerative medicine work? I am often asked of this question by my patients.

The body has an innate capacity to heal by replacing dying or injured cells and rejuvenating itself. We have this capacity at any age. The goal of regenerative medicine is to restore structure and function of a damaged tissue or an organ by using the body’s innate ability to heal. This is different from most modern medical treatment modalities which only manage conditions without any potential to actually heal. For example, if you have osteoarthritis and you take ibuprofen to reduce the pain and inflammation or you receive an injection into a joint with a compound such as a steroid or a lubricating agent.

Cellular and stem cell activating treatments are a very big and complex subject because the number of conditions that can be treated is vast. I would like to discuss just a few treatments that we perform as a starter and discuss more in future blogs.

Let’s start with osteoarthritis of the knee, hip or shoulder joints. As we age, we are all going to develop varying degrees of osteoarthritis of the joints. It is part of the aging process due to the normal wear and tear that our joints undergo as we go through life. Some people have it more in the hips, some people have it more in the knees, some people have it more in the hands, but it is a very common malady of humans. Regenerative medicine stem cell activating treatments are aimed at helping to restore structure and function, not just reducing inflammation or blocking pain receptors in the brain. That means that the joint is going to work better and it is not going to be as painful.

Let’s talk about hair loss which is a very common issue, particularly in men. It may not be a health issue, but it is something that bothers a lot of people. Regenerative medicine treatments can help hair follicles that are still alive to produce thicker hair and more hair. If the follicle is dead and totally gone, nothing is going to regrow a follicle. But, if the follicle is still there, even if one little tiny thin hair is coming out, regenerative medicine treatments can help that follicle produce thicker hair and more hairs out of the follicle.

Now, let’s talk about neurodegenerative conditions such as dementia and peripheral neuropathy. Both of these conditions can be improved by regenerative medicine treatments. Let’s take dementia today for example. One very common type of dementia is Alzheimer’s disease. Many doctors throughout the world have had excellent success in treating this condition with a regenerative medicine cellular treatment known as neuroregenesis. Though not a cure for the disease, noticeable and measurable positive outcomes usually occur. This treatment can address significant deterioration of brain dysfunction as well as with stages of forgetfulness. The treatment has been able to bring many people who are severely limited back into a more normal life and a more normal interaction with their families. It is also a useful treatment to help reverse aging related minor decline of brain function. For example, when someone feels as if their mind is not as sharp or quick as when they were younger, this regenerative medicine treatment can help.

The important thing to remember is that the goal of stem cell activating treatments is to restore structure and function of damaged tissues and organs. It works in part by the body’s innate ability to heal and rejuvenate. It is a very powerful and proven medical breakthrough.

Regenerative Medicine Treatments for Common Conditions

Regenerative Medicine Treatments for Common Conditions

Regenerative medicine works by harnessing our body’s innate ability to repair damaged tissue and to restore structure and function to damaged areas of the body.  A good example of this is the ability to treat an arthritic joint without surgery or harmful steroid injections.  These regenerative treatments are truly a game changer as compared with the standard tools and treatments of modern medicine.  For example, drug interventions such as ibuprofen, steroid injections or lubricating injections for joint pain are not healing the cartilage of the joint.  At best, they help manage the painful conditions or block the pain temporarily. These interventions do not address the root causes of the pain and have significant side effects.  This also applies to many other types of degenerative conditions such as spinal disc degeneration, hair loss or neuronal degeneration which can lead to memory problems.  Regenerative medicine on the other hand operates on a completely different principle. The goal of regenerative medicine is to help the body heal and thus enable the body to return as close as possible to its normal function and structure. The same principle applies to all of these structures.

Let’s use the same example of treating an injured or arthritic joint, such as the knee or hip joint.  A routine regenerative medicine treatment would be a stem cell activating guided joint injection procedure.  Stem cells have innate intelligence and the unique capacity to help in multiple ways.  For example, they will recognize the damage to the joint and initiate the healing process.

You might wonder how could stem cells recognize damage to a joint or organ?   It is actually an extremely fascinating and well researched phenomenon.  There is an innate intelligence in all aspects of our body and in any living organism, including single cells, to assess the local environment.   A single cell can sense chemical distress molecules that a damaged cartilage cell releases when it’s dying or injured.  Stem cells not only can sense those molecules and will be attracted to the damaged area, they can send out their own molecules to signal other stem cells from the reservoir of stem cells that everybody has in the body, to migrate into the damaged joint and help in the healing process. Stem cells can also excrete molecules that the weakened cell needs to nurse it back to health.  Stem cells can even donate mitochondria to damaged cells. Mitochondria are the powerhouse of the cells and are essential for cell life.  These are very powerful healing properties that stem regenerative medicine treatments have that can help to heal and restore structure and function.

To reiterate, our bodies have an innate ability to repair damaged tissue and heal at any age. Regenerative medicine activates this powerful healing ability of our body.

We discussed joints, now let’s talk about hair.   As we age, many of us start losing hair follicles.  They become less effective in producing hair, they produce thinner hair and eventually die.  Some of us are lucky enough not to have thinning hair, but it’s a very common issue that most people face.   Regenerative medicine is a powerful treatment that can potentially increase the amount of hair per follicle and the thickness of the hair.  If the hair follicle is completely dead, such as when the scalp is bald and there are absolutely no hair follicles, it’s not going to replace those hair follicles with new hair follicles.  But, in the initial stages of thinning hair when the hair follicles produce less  hair and thinner pieces of hair, the regenerative treatment has the significant potential to reverse the thinning process.

Another great treatment with regenerative medicine is to help improve brain function in patients with various dementia conditions such as Alzheimer’s.  Regenerative medicine helps to restore various neuronal interconnections and helps nourish various nerve cells back to health. It is not a cure for the condition and is not going to turn someone with dementia whose brain is severely compromised back into how they were when they were young.   However, it’s a very promising and exciting treatment with significant clinical evidence of slowing down and often improving memory loss.