The goal of regenerative medicine procedures in general is to restore structure and function of damaged tissues and organs, and that is a very important point that distinguishes regenerative medicine procedures from conventional medicine procedures. For example, we are not trying to just stop pain or to improve a joint through lubricating it or administering an anti-inflammatory medication. The goal of the regenerative treatment is to restore the normal structure and function of the damaged tissue.
I previously discussed what are commonly referred to as stem cell treatments, which is a cellular regenerative medicine treatment, and now I am going to talk about non-cellular regenerative medicine treatments. The difference is that non-cellular treatments do not contain cells. Some of these treatments are cellular products such as proteins, but they are not cells. That’s the difference between the two types of treatments, but the mechanism of actions and the treatment goals are very similar. More specifically, the goal is the same and the action is similar.
It is very important for a doctor to be well-versed in both non-cellular and cellular treatments in order to be able to determine which specific treatment is more likely to help a specific patient for a specific condition. This is why we call what we do personalized precision medicine.
I could use one of a number of non-cellular or cellular treatments to address a very similar condition in different patients. One might ask, why are you using a different treatment for the same condition? The reason is that everybody is different. Everybody responds differently to the same treatment, and every person’s condition is unique. Take high blood pressure as an example. We all know that there are many blood pressure medications on the market. If every medication works the same on every person, we would only need one blood pressure medication. So, part of my job is to determine what treatment is most likely to help a specific patient for his or her specific condition.
Let’s start with oxygen ozone injection therapy which is a non-cellular regenerative treatment. Oxygen ozone injection therapy is an extremely powerful regenerative medicine treatment. It helps cells increase in number, which is called proliferation, by favorably influencing the redox system, which controls the cell cycle. It also has multiple other properties such as increasing oxygen delivery to tissues and reducing inflammation in the body. I have had a lot of successes using this injection therapy treating patients with disc herniations, joint pain, sports injuries and muscle spasm because of these unique properties. Oxygen ozone can also be used to stimulate hair follicles to reproduce more hair and thicker hair by the same mechanisms that I described above.
Another non-cellular product with regenerative properties is exosomes. Exosomes are an extremely fascinating cellular excretion product. Exosomes are vacuoles that are excreted by cells which contain messenger RNA, micro RNA, and proteins. They are very powerful in activating the body’s own stem cells to help rejuvenate and repair damaged structures. For example, exosomes can potentially stimulate repair of damaged cartilage, skin and nervous tissue which is a very powerful non-cellular regenerative repair mechanism within our body’s own amazing ability to heal.
A2M is another powerful non-cellular regenerative medicine treatment. A2M is a protein that is naturally found in our body which can be concentrated and injected into various structures such as joints and discs. A2M will capture and deactivate proteins that destroy cartilage. It is a very important treatment if cartilage is being destroyed in a joint or in a disc since A2M can stop the process. It also has growth factor binding sites, so it has regenerative properties.
These are some of the many treatments with non-cellular regenerative medicine. Since I wrote a previous blog discussing cellular regenerative medicine treatments, I won’t go into it again. The most important point, as I discussed above, is for a doctor to be well versed in all types of regenerative medicine treatments in order to be able to determine which of these non-cellular or cellular treatments are most appropriate for a specific patient in order to give the patient the best chance of healing.