The safety and efficacy of ozone disc injection therapy – A follow up

After I posted about the original Moto research on the safety and efficacy of ozone disc injection therapy last week.  Several patients have asked me where they can locate other trustworthy and reputable medical research publications on ozone injection therapy in general.   I have compiled the following research for you, these are a few most significant studies on ozone injections therapy including my last post Dr. Moto’s research.


  1. In 2008, Muto (Muto et al: Radiol med (2008) 113:695-706) reported the treatment of 2,900 patients with oxygen-ozone injection procedures for painful disc conditions. It was noted that 75 to 80 percent of patients with a single disc herniation, and 70 percent of patients with multiple disc herniations, had significant improvement in their symptoms after the procedure. None of the patients developed neurologic or infectious complications.
  2. In 2009, Dr. Kieran Murphy, who is an interventional radiologist at University of Toronto, addressed the Society of Interventional Radiology in San Diego. Dr. Murphy reported data from 12 studies encompassing more than 8,000 patients with painful disc conditions. 79.7 percent of ozone injected patients improved in at least 1 category of a modified pain and functional scale. The recovery time was significantly shorter than surgical discectomy. The complication rate was extremity low. The complication risk was calculated as 0.003 percent. There were no serious complications reported. The patient ages ranged from 13 to 94 years of age. In recent years, studied were published to further the ground breaking work of Dr. Muto and Dr. Murphy.
  3. Five and Ten Year Follow-up on Intradiscal Ozone Injection for Disc Herniation, International Journal of Spine Surgery Click to Read
  4. Ozone and Placebo in the Treatment of Knee Osteoarthritis, American College of Rheumatology, September 2015 Click to Read
  5. Comparison Between Intra Articular Ozone and Placebo in the Treatment of Knee Osteoarthritis: A Multicentric, Comparative, Randomized and Double-Blinded Clinical Trial, Presentation at American College of Rheumatology, September 29, 2015 Click to Read
  6. SIR: Ozone Shots As Effective As Surgery For Back Pain, March, 2009
  7. Low Back Pain and Sciatica: Treatment with Intradiscal-Intraforaminal O2-O3Injection. Our Experience. M. Muto, July 2008
  8. CT-guided Oxygen-Ozone Treatment for First Degree Spondylolisthesis and Spondylolysis, M. Bonetti, 2005
  9. The Medical Society for the Use of Ozone in Prevention and Therapy

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