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What to Expect During a Muscle Pain Injection Procedure

December 19, 2025

A doctor gives a muscle pain injections to a patient.

In short,

  • Muscle pain injections target trigger points with medication to relax tight muscle bands and reduce inflammation
  • The procedure takes only minutes in an office setting, with most patients experiencing relief within 24 to 72 hours
  • Injections work best when combined with physical therapy and lifestyle modifications for lasting pain relief

Understanding Muscle Pain Injections

Muscle pain injections are a targeted treatment option for persistent muscular discomfort that has not responded adequately to conservative measures. The best injection for muscle pain delivers medication directly into affected muscle tissue, addressing painful trigger points that cause chronic muscle tension and referred pain.

These injections represent an important tool in comprehensive pain management, particularly for patients experiencing myofascial pain syndrome. When muscles develop tight, irritable bands with hyper-sensitive nodules called trigger points, the result can be localized pain, referred pain to distant areas, muscle weakness, and a restricted range of motion that interferes with daily activities.

What Are Trigger Points?

Trigger points are hyperirritable spots within taut bands of skeletal muscle that feel like firm knots when you touch them. These sensitive areas develop when muscle fibers remain in a contracted state, creating localized muscle tension and pain.

When pressure is applied to a trigger point, it produces local pain directly at the trigger point site and referred pain that radiates to other areas in predictable patterns. For example, trigger points in the upper trapezius muscle commonly cause tension headaches, while trigger points in the piriformis muscle can produce symptoms similar to sciatica.

Myofascial pain affecting trigger points is remarkably common, with studies indicating that up to 85 percent of people experience trigger point discomfort at some point during their lifetime.

Common Causes of Trigger Points

Muscle overload from repetitive movements or sustained positions is a primary trigger point cause. Office workers who maintain forward head posture for extended periods, athletes who perform repetitive overhead motions, and manual laborers who lift heavy objects regularly are all at increased risk.

Acute trauma from falls, accidents, or sudden muscle strain can create trigger points that persist long after the initial injury heals. Poor posture places chronic stress on certain muscle groups, while emotional stress causes sustained muscle tension that can evolve into chronic trigger points.

Underlying conditions like vitamin D deficiency, hypothyroidism, or structural abnormalities may predispose some individuals to developing myofascial pain syndrome.

Types of Medication Used

The best injection for muscle pain depends on your specific condition, symptom severity, and treatment goals.

Local Anesthetics

Local anesthetics like lidocaine are the most commonly used medications for trigger point injections. These medications block pain receptors in the affected area, providing immediate relief and allowing the muscle to relax.

The numbing effect typically lasts several hours, giving the muscle time to release its tension.

Corticosteroids

Corticosteroids reduce inflammation in the muscle and surrounding connective tissue. When combined with local anesthetics, corticosteroids may extend pain relief by addressing underlying inflammation.

Other Options

Botulinum toxin interferes with nerve signaling pathways that cause muscle contractions, producing sustained muscle relaxation that can last several months. This option is typically reserved for persistent trigger points that have not responded to other treatments.

Some practitioners also perform dry needling, which involves inserting a needle into the trigger point without injecting medication, with the mechanical action itself providing relief.

The Injection Procedure

Understanding what happens during the procedure helps reduce anxiety and prepare you for what to expect.

Before the Injection

No special preparation is typically required. However, inform your healthcare provider about all medications you take, particularly blood thinners, and any allergies to latex or local anesthetics. Your provider will perform a physical examination to locate your trigger points by palpating the affected muscles.

During the Procedure

The injection procedure takes only a few minutes and is performed in an office setting. Your provider will clean the injection site with an antiseptic and may mark the exact trigger point location on your skin.

A thin needle is inserted through your skin directly into the trigger point. You will likely feel a brief stinging or burning sensation. When the needle tip touches the trigger point, you may experience a momentary increase in pain and feel your muscle twitch or spasm. This twitch response indicates the needle has reached the correct location.

Your provider will gently move the needle in multiple directions without fully removing it, a technique called needling. This mechanical disruption helps release the taut muscle band. Once the muscle feels adequately relaxed, the medication is injected if you are receiving a wet injection rather than dry needling. The entire procedure typically takes five to ten minutes.

After the Injection: What to Expect

You can go home immediately after the procedure and resume most normal activities. However, rest the treated muscle for one to two days following the injection. Avoid activities that strain the muscle, such as heavy lifting, high-intensity exercise, or maintaining positions that stress the treated area for prolonged periods.

Do not apply heat to the injection site for 24 hours, as heat can increase bleeding. After the first day, you may apply ice packs for 10 minutes at a time if helpful. Some people prefer gentle heat after the first 24 hours to promote muscle relaxation.

Timeline for Pain Relief

Pain relief typically begins between 24 and 72 hours after the injection as inflammation subsides and the muscle fully releases. The duration of relief varies but generally lasts around one month or longer. Some patients experience extended relief, particularly when injections are combined with physical therapy and lifestyle modifications.

Side Effects

Mild side effects are common and usually resolve within a few days, including soreness at the injection site, minor bruising or swelling, and a temporary increase in pain during the first 24 hours before relief begins.

Risks and Complications

While muscle pain injections are generally safe when performed by experienced providers, rare complications include infection at the injection site, bleeding or hematoma formation, particularly in patients taking blood thinners, allergic reactions to medications used, and nerve injury if the needle inadvertently contacts a nerve.

Contact your healthcare provider if you experience a fever of 100.4 degrees Fahrenheit or higher, severe or worsening pain at the injection site, signs of infection, including increasing redness, warmth, or drainage, or numbness or weakness that was not present before the injection.

Conditions Treated

Muscle pain injections effectively treat several chronic muscle conditions.

  • Myofascial pain syndrome, characterized by regional muscle pain associated with trigger points, is the primary indication.
  • Fibromyalgia patients may experience relief from trigger point injections targeting specific areas of muscle tenderness.
  • Tension headaches caused by muscle spasms in the scalp and neck often improve with injections to affected muscles.
  • Temporomandibular joint syndrome involving jaw muscle pain, complex regional pain syndrome, piriformis syndrome, and chronic neck or back pain with identifiable trigger points are additional conditions that may benefit from this treatment.

Best Injection for Muscle Pain in Caldwell, New Jersey

If you are experiencing chronic muscle pain that has not responded to conservative treatments, a professional evaluation can determine whether the best injection for muscle pain might provide the relief you need. Our experienced team specializes in diagnosing and treating myofascial pain syndrome with comprehensive, patient-centered care.

Call Alternative Disc Therapy today at (973) 403-3334 or schedule a consultation online to discuss whether muscle pain injections are right for you.

Filed Under: Muscle Pain Tagged With: best injection for muscle pain, Best Injection for Muscle Pain in Caldwell, Chronic Muscle Pain, Corticosteroids, muscle spasms, pain management, physical therapy

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Dr. Warren J. Bleiweiss at Alternative Disc Therapy provides a number of non-surgical pain relief treatments including Ozone Herniated Disc Treatment, Ozone Injection Treatments for Joint and Muscle Pain, Photo Activated PRP Treatments, Upstream Anti-Aging Treatments, Immune Optimizing Infusions, Stem Cell Treatments, and Total Spine Health Treatments.